February places a national spotlight on cardiovascular wellness, but for cardiologists and supplement brands, heart health is a year-round priority. Cardiovascular disease remains a leading cause of mortality worldwide, and patients are increasingly proactive about prevention. As a result, the heart health supplement category continues to grow, driven by clinical research, consumer awareness, and demand for science-backed products.
For health brands looking to expand or refine their product lines, understanding the top-selling heart health supplements is critical. For cardiologists, knowing which ingredients patients are using helps guide evidence-based conversations. At Makers Nutrition, we partner with brands to develop high-quality, custom heart health supplements that align with current research and evolving market demand.
This article explores the top-selling supplements for heart health, the science behind them, and how brands can strategically position these products in a competitive marketplace.
The Growing Demand for Heart Health Supplements
Consumers are more informed than ever. They research ingredients, read clinical studies, and expect transparency in labeling and sourcing. Preventive cardiology has become mainstream, and many patients now incorporate dietary supplements alongside lifestyle changes and prescribed therapies.
Several trends are driving sales in the cardiovascular supplement space:
- An aging population focused on longevity
- Increased screening for cholesterol and blood pressure
- Consumer interest in natural and complementary approaches
- Greater physician openness to certain evidence-based nutraceuticals
For brands, this presents a clear opportunity. However, success requires more than simply adding a fish oil capsule to a catalog. Formulation quality, bioavailability, regulatory compliance, and manufacturing excellence all play central roles. Makers Nutrition supports brands at every stage, from concept development and ingredient sourcing to encapsulation, bottling, labeling, and fulfillment.
Now let us explore the top-selling heart health supplements that continue to dominate the market.
Omega-3 Fatty Acids
Omega-3 fatty acids consistently rank among the best-selling heart health supplements. Fish oil products containing EPA and DHA are widely recognized for their role in cardiovascular support.
Scientific Support
Clinical research suggests that omega-3 fatty acids may help:
- Support healthy triglyceride levels
- Promote normal inflammatory responses
- Contribute to overall cardiovascular function
Large-scale studies have evaluated EPA and DHA in various cardiovascular contexts, including lipid management and secondary prevention. While outcomes vary based on dosage and formulation, omega-3 supplementation remains one of the most studied interventions in the nutraceutical space.
Market Appeal
Consumers associate omega-3 supplements with heart health almost automatically. This familiarity drives strong retail and online sales. However, the market is crowded. Brands that differentiate through high-potency formulas, enteric coatings, or algae-based vegan options tend to stand out.
At Makers Nutrition, we help brands develop softgel, capsule, and liquid omega-3 products using quality-tested raw materials that meet strict manufacturing standards.
Coenzyme Q10
Coenzyme Q10, often referred to as CoQ10, is another top-selling cardiovascular supplement. It plays a critical role in mitochondrial energy production and functions as an antioxidant.
Scientific Support
Research indicates that CoQ10 may:
- Support cellular energy production in cardiac muscle
- Help maintain healthy blood pressure levels
- Assist patients who are taking statins, as statin therapy may reduce endogenous CoQ10 levels
For cardiologists, CoQ10 often becomes part of the conversation when discussing muscle-related side effects or energy support in patients on lipid-lowering medications.
Market Appeal
CoQ10 is popular among middle-aged and older consumers focused on heart health and vitality. Ubiquinol, the reduced form of CoQ10, has gained traction due to its enhanced bioavailability.
Brands can differentiate by offering clinically relevant dosages, combination formulas with omega-3s, or premium ubiquinol softgels. Makers Nutrition provides turnkey manufacturing solutions for CoQ10 capsules and softgels, ensuring potency and stability throughout shelf life.
Magnesium
Magnesium is frequently overlooked, yet it remains a top-selling mineral for cardiovascular support. It plays a role in muscle contraction, nerve signaling, and vascular tone.
Scientific Support
Magnesium contributes to:
- Maintenance of normal blood pressure
- Proper cardiac rhythm
- Electrolyte balance
Low magnesium status has been associated with increased cardiovascular risk in observational studies. Supplementation may be particularly relevant for individuals with dietary insufficiency.
Market Appeal
Magnesium appeals to a broad audience because it also supports sleep, stress management, and muscle recovery. Forms such as magnesium glycinate, citrate, and taurate are popular for their absorption profiles and tolerability.
For heart-focused products, magnesium taurate and magnesium glycinate are especially attractive due to their gentle impact on digestion and alignment with cardiovascular wellness messaging.
Makers Nutrition assists brands in selecting the most appropriate magnesium form based on target demographics, dosage requirements, and label claims.
Plant Sterols and Stanols
Plant sterols and stanols have long been associated with cholesterol management. They are commonly found in fortified foods, but supplement formats remain strong sellers.
Scientific Support
Research shows that plant sterols can:
- Reduce intestinal absorption of dietary cholesterol
- Support healthy LDL cholesterol levels when consumed in adequate amounts
These compounds structurally resemble cholesterol and compete for absorption in the digestive tract.
Market Appeal
Consumers seeking natural cholesterol support often gravitate toward plant-based products. Capsules and chewable tablets are common delivery systems.
For brands, proper dosing is essential, as clinical studies typically use specific daily intake levels to demonstrate efficacy. Makers Nutrition works closely with brands to ensure accurate formulation and compliance with labeling regulations.
Garlic Extract
Garlic has been used traditionally for cardiovascular support for centuries. Modern standardized extracts have brought scientific rigor to this ancient remedy.
Scientific Support
Some studies suggest that garlic supplementation may:
- Support healthy blood pressure levels
- Promote favorable lipid profiles
- Provide antioxidant activity
Standardized extracts that contain specific amounts of active compounds tend to be preferred in clinical research.
Market Appeal
Garlic appeals to consumers seeking traditional, plant-based heart support. Odor-controlled formulations are particularly popular, as they address common concerns about aftertaste.
Makers Nutrition can manufacture odor-controlled garlic capsules that maintain potency while improving consumer experience.
Emerging Ingredients Gaining Momentum
While the supplements above represent established top sellers, several emerging ingredients are gaining attention among cardiologists and forward-thinking brands.
Berberine
Berberine has attracted interest for its potential effects on lipid metabolism and blood sugar regulation. Early research suggests it may support healthy cholesterol and triglyceride levels. As clinical data grows, berberine-based heart formulas are becoming more common.
Aged Garlic Extract
Aged garlic extract differs from standard garlic powder and has been studied for vascular health and arterial flexibility. Premium brands are increasingly incorporating this ingredient into advanced cardiovascular formulas.
Vitamin K2
Vitamin K2 plays a role in calcium metabolism and vascular health. Interest in K2 has grown as researchers explore its relationship with arterial calcification. Combined vitamin D3 and K2 formulas are particularly popular in preventive wellness categories.
Makers Nutrition stays ahead of ingredient trends by sourcing high-quality raw materials and offering research-informed formulation guidance.
What Cardiologists Want to See in Supplement Formulations
For cardiologists, ingredient selection is only part of the equation. Quality control, dosing accuracy, and transparency are equally important.
Physicians increasingly ask patients about supplement use. When brands prioritize:
- Clinically relevant dosages
- Third-party testing
- Transparent labeling
- Good Manufacturing Practice compliance
They build credibility with healthcare professionals.
Makers Nutrition operates in an FDA-registered and GMP-compliant facility, giving brands confidence that their heart health products meet strict quality standards.
Strategic Opportunities for Health Brands
To succeed in the competitive cardiovascular category, brands must think strategically.
Focus on Combination Formulas
Multi-ingredient formulas that combine omega-3s, CoQ10, magnesium, and plant extracts can offer comprehensive heart support. Thoughtful formulation ensures synergy without excessive capsule counts.
Emphasize Education
Cardiologists appreciate educational materials grounded in scientific literature. Brands that provide white papers, ingredient summaries, and research references position themselves as credible partners.
Prioritize Delivery Format Innovation
Softgels remain popular for lipid-based ingredients, while capsules and powders offer versatility. Gummies are expanding into the heart health space, especially for younger demographics seeking preventive support.
Makers Nutrition offers turnkey manufacturing across multiple delivery formats, helping brands select the most beneficial and marketable option.
Manufacturing Excellence Matters
Heart health is not a casual category. Consumers purchasing these products often have serious health concerns or strong preventive goals. Quality failures can damage brand reputation quickly.
At Makers Nutrition, we support health brands with:
- Custom supplement formulation
- Ingredient sourcing and verification
- Encapsulation, tableting, and softgel production
- Label design and packaging
- Order fulfillment and logistics
Our turnkey supplement manufacturing model allows brands to bring science-driven cardiovascular products to market efficiently and confidently.
Building Trust Amongst Consumers
Heart health supplements remain one of the most stable and high-performing categories in the nutraceutical industry. Omega-3 fatty acids, CoQ10, magnesium, plant sterols, fiber, and garlic extracts continue to dominate sales, supported by a growing body of scientific research.
For cardiologists, understanding these products helps guide informed patient discussions. For health brands, success depends on evidence-based formulation, quality manufacturing, and strategic differentiation.
As demand for preventive cardiovascular support continues to grow, partnering with an experienced supplement manufacturer becomes essential. Makers Nutrition stands ready to help brands develop, manufacture, and scale top-selling heart health supplements that meet both scientific standards and consumer expectations.
By combining research-driven ingredients with manufacturing excellence, brands can deliver meaningful cardiovascular support while building long-term trust in a competitive marketplace.